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Venn diagram showing <t>the</t> <t>SOMAmer</t> overlap (based on “SeqId” identifiers) between the 1.3K, 5K, <t>7K,</t> and 11K SomaScan assays.
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Image Search Results


Venn diagram showing the SOMAmer overlap (based on “SeqId” identifiers) between the 1.3K, 5K, 7K, and 11K SomaScan assays.

Journal: bioRxiv

Article Title: SomaScan Bioinformatics: Normalization, Quality Control, and Assessment of Pre-Analytical Variation

doi: 10.1101/2024.02.09.579724

Figure Lengend Snippet: Venn diagram showing the SOMAmer overlap (based on “SeqId” identifiers) between the 1.3K, 5K, 7K, and 11K SomaScan assays.

Article Snippet: For each human protein SOMAmer in the plasma 7K assay, we calculated the Spearman’s correlation between the fully normalized RFU values from the adat file provided by SomaLogic using external references (a file designated with the “hybNorm.medNormInt.plateScale.calibrate.anmlQC.qcCheck.anmlSMP” suffix) and the full normalization described here using internal references (“hyb.msnCal.ps.cal.msnAll”).

Techniques:

Distribution of Spearman’s correlation estimates for the 7,289 human protein SOMAmers in the 7K plasma SomaScan assay, calculated over nearly 1,800 human donor samples from the BLSA . For each SOMAmer, the correlation was calculated between the fully normalized RFU values from SomaLogic’s pipeline using external references and the full normalization described here using internal references.

Journal: bioRxiv

Article Title: SomaScan Bioinformatics: Normalization, Quality Control, and Assessment of Pre-Analytical Variation

doi: 10.1101/2024.02.09.579724

Figure Lengend Snippet: Distribution of Spearman’s correlation estimates for the 7,289 human protein SOMAmers in the 7K plasma SomaScan assay, calculated over nearly 1,800 human donor samples from the BLSA . For each SOMAmer, the correlation was calculated between the fully normalized RFU values from SomaLogic’s pipeline using external references and the full normalization described here using internal references.

Article Snippet: For each human protein SOMAmer in the plasma 7K assay, we calculated the Spearman’s correlation between the fully normalized RFU values from the adat file provided by SomaLogic using external references (a file designated with the “hybNorm.medNormInt.plateScale.calibrate.anmlQC.qcCheck.anmlSMP” suffix) and the full normalization described here using internal references (“hyb.msnCal.ps.cal.msnAll”).

Techniques: Clinical Proteomics